Slide DMS061 [Monkey; liver]. Now that you know what to look for, try to define classic hepatic lobules in this liver section. Identify: central veins, portal spaces and hepatic triad components. Look at the hepatic parenchymal cells (hepatocytes). Note that they appear cuboidal in section (actually most are 14- sided, dodecakaihedral-shaped cells) and are arranged in plates one cell thick, usually separated by blood sinusoids. Many cells are binucleate and some have an unusually large nucleus. The hepatic sinusoids usually contain some blood cells (unless the liver was fixed by perfusion). The sinuosoids are lined by highly fenestrated endothelial cells and phagocytic von Kupffer cells ("fixed macrophages"), but these are not easily discerned in this preparation. Refer to your textbooks for correlative fine structure (EM) details of hepatocytes and sinusoids. Attempt to identify bile ductules (canals of Hering) that connect the canaliculi to the interlobular bile ducts, but do not spend too much time on this endeavour since the fortuitous sections clearly demonstating these are few and far-between.